Monoclonal antibody binding to congophilic elements in human Alzheimer brain

Abstract

Immunohistochemical studies, using a monoclonal antibody, SMP, raised in a mouse against aged human peripheral blood white cells, are described. This antibody reacts with dendritic reticulum cells in lymph node and tonsil, and, in Alzheimer brain, with argyrophilic plaques, neurofibrillary tangles, and cerebral vascular amyloid.