Matrix-induced autologous chondrocyte implantation

Abstract

Matrix-induced autologous chondrocyte implantation (MACI) by means of direct inoculation of chondrocytes on a type I/IV collagen membrane for surgical implantation is less invasive and obviates periosteal harvest and suturing in most cases. It allows manufacturers to deliver a standard cell density for implantation. This chapter describes the characteristics of collagen membrane and the surgical procedures of MACI. The early clinical results based on 43 implantations in 40 patients were reported. It concluded that MACI achieves a comparable functional and histological outcomes as does conventional ACI technology. © 2007 Humana Press Inc.