Core-shell eudragit S100 nanofibers preparedvia triaxial electrospinning to providea colon-targeted extended drug release

Abstract

In this study, a new modified triaxial electrospinning is implemented to generate an EudragitS100 (ES100)-based core-shell structural nanofiber (CSF), which is loaded with aspirin. The CSFs havea straight line morphology with a smooth surface, an estimated average diameter of 740±110 nm, and a clear core-shell structure with a shell thickness of 65 nm, as disclosed by the scanningelectron microscopy and transmission electron microscopy results. Compared to the monolithiccomposite nanofibers (MCFs) produced using traditional blended single-fluid electrospinning, aspirin presented in both of them amorously owing to their good compatibility. The CSFs showedconsiderable advantages over the MCFs in providing the desired drug-controlled-release profiles, although both of them released the drug in an erosion mechanism. The former furnished alonger time period of time-delayed-release and a smaller portion released during the first two-houracid condition for protecting the stomach membranes, and also showed a longer time period ofaspirin-extended-release for avoiding possible drug overdose. The present protocols provide apolymer-based process-nanostructure-performance relationship to optimize the reasonable deliveryof aspirin.