HLA-DR-matched parental donors for allogeneic hematopoietic stem cell transplantation in patients with high-risk acute leukemia

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Abstract

The immunomodulating effect of human leukocyte antigen (HLA)-DR and the central role of CD4 T cells in alloimmunity provide clues suggesting that HLA-DR-matched, partially mismatched related donors could be feasible alternative donors of allogeneic hematopoietic stem cells for transplantations (alloHSCT). We describe our experience with allo-HSCT in eight patients with high-risk acute leukemia; donors included one of each of the parents. Among the eight patients, seven were identical HLA-DR matches with the donors. The stem cells were not manipulated in vitro. Graft-versus-host disease (GVHD) prophylaxis consisted of antithymocyte globulin, cyclosporine, and methotrexate. All patients had successful trilineage engraftment. Only one patient had grade 2-4 acute GVHD. Two patients died before day +100 due to complications. At the end of follow-up, four patients had survived for 18-48 months and three are alive and without relapse. Our results suggest that HLA-DR fully-matched parents are feasible alternative donors for allo-HSCT in patients with high-risk acute leukemia under an intensive conditioning regimen. ©2009 Elsevier & Formosan Medical Association.

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APA

Wu, S. J., Yao, M., Tang, J. L., Ko, B. S., Tien, H. F., & Chen, Y. C. (2009). HLA-DR-matched parental donors for allogeneic hematopoietic stem cell transplantation in patients with high-risk acute leukemia. Journal of the Formosan Medical Association, 108(5), 423–427. https://doi.org/10.1016/S0929-6646(09)60087-5

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