Determination the effect of ciprofloxacin and gentamicin alone and in combination to induce nephrotoxicity in experimental rats

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Abstract

This study aimed to evaluate the combination effects of ciprofloxacin (CP) and gentamicin (GT) in compare to their lonely effect to induced nephrotoxicity in experimental rats for (14) days administration. Doses of 100 mg/kg were used for each of CP and GT, and 50mg/kg each of CP and GT were combined to estimate the synergistic effect of two drugs. In this study we used 28 rats which were randomly divided into 4 groups (n= 7 in each group), grpup1: animals were given saline (NaCl; 0.9%) 1 ml/kg orally for 14days, group2: CP alone at dose of 100 mg/kg orally for (14) consecutive days was given, group3: animals were given GT alone at dose of 100 mg/kg intraperitoneally (i/p) for (14) consecutive days, and the group 4: animals were treated with combination of GT (50mg/kg IP) and CP (50 mg/kg orally) for (14) consecutive days. After 2 weeks, the blood had been draw for biochemical evaluation and kidney sections had been take for histopathological examination. Nephrotoxicity was estimated by measuring biochemical markers: the serum creatinine (Cr), blood urea nitrogen (BUN) and Malondialdehyde (MDA) levels. The results of this study showed that there were significant (p< 0.05) or (p< 0.01) increase in Cr, BUN, MDA in combination of GT and CP groups than other groups. The administration of the combination GT with CP result in significant increase of nephrotoxicity in compare to administration of GT and CP alone respectively.

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Hashim, M. U., Ali Al-Cekal, S. H., & AL-Khamas, A. J. H. (2020). Determination the effect of ciprofloxacin and gentamicin alone and in combination to induce nephrotoxicity in experimental rats. Annals of Tropical Medicine and Public Health, 23(7). https://doi.org/10.36295/ASRO.2020.23731

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