Although on-treatment reactivity (OTR) while receiving clopidogrel is strongly associated with CYP2C19 genotype, the majority of the hereditability in clopidogrel response variability remains unexplained, supporting the contention that other important genetic determinants have yet to be identified.
Price, M. J., Carson, A. R., Murray, S. S., Phillips, T., Janel, L., Tisch, R., … Levy, S. (2012). FIRST PHARMACOGENOMIC ANALYSIS USING WHOLE EXOME SEQUENCING TO IDENTIFY NOVEL GENETIC DETERMINANTS OF CLOPIDOGREL RESPONSE VARIABILITY: RESULTS OF THE GENOTYPE INFORMATION AND FUNCTIONAL TESTING (GIFT) EXOME STUDY. Journal of the American College of Cardiology, 59(13), E9. https://doi.org/10.1016/s0735-1097(12)60010-2