Modeling and simulation of ciprofloxacin pharmacokinetics: Electric circuits approach

Abstract

The development of models that fit to behavior of the drug pharmacokinetics and quantitatively describe the concentration-time relationship plus its integration with the development of tools that allow to implement them in clinical practice to model and simulate the better clinical outcomes are recommended to promote the rational use of drugs. It relies on the development of models that describe the body as a set of compartments and transitions. These models are then represented by a set of ordinary differential equations. This article discusses the development of a pair of circuital models that describes the pharmacokinetics of ciprofloxacin, a broad spectrum antibiotic and their fitting to experimental data previously published. As a result, there is no relevant difference between the RLC model and the RC model, the fitting algorithm used found that L should be zero reducing the RLC model to a RC model, showing that a first order model is sufficient for modeling pharmacokinetics of ciprofloxacin.