Preeclampsia and prevalence of microalbuminuria 10 years later

Abstract

Background and objectives A recentmeta-analysis found that about 30%ofwomenwith a previous preeclamptic pregnancy had persistent microalbuminuria at follow-up. The analysis was, however, based on small studies, and more data are needed. Design, setting, participants, & measurements Using data from the Medical Birth Registry in Norway, this study identified women with or without preeclampsia in their first pregnancy 9-11 years previously (1998-2000). Women with diabetes, rheumatic disease, essential hypertension, or renal disease before first pregnancy and/or preeclampsia in later pregnancieswere excluded. Eighty-ninewomenwith and 69womenwithout preeclampsia participated in the study. Urinary albumin-to-creatinine ratio (ACR) was measured in three morning urine samples. Estimated GFR (eGFR) was calculated using the CKD-Epidemiology Collaboration formula. Results Median urinaryACR in follow-up urine sampleswas 0.53mg/mmol forwomenwith and 0.50 mg/mmol for women without preeclampsia (P=0.54). Only one woman (1%) with previous preeclampsia had urinary ACR>2.5mg/mmol in two of three urine samples. Preeclampsiawas not associatedwith urinary ACR above the 75th percentile.Women with preeclampsia did not have significantly higher eGFR than womenwithout preeclampsia (107.9 versus 104.9 ml/min per 1.73 m2; P=0.12), but preterm preeclampsia was significantly associated with eGFR above the 75th percentile (P=0.03). Conclusions In this population-based study of otherwise healthy women, preeclampsia 10 years earlier was not associated with increased risk of persisting microalbuminuria. Estimated GFR was not significantly different between women with and those without preeclampsia, but preterm preeclampsia was associated with high normal eGFR. © 2013 by the American Society of Nephrology.