Solvent-dependent regioselective oxidation of trans-chalcones using aqueous hydrogen peroxide

Abstract

A novel method for regioselective oxidation of trans-chalcones with hydrogen peroxide in acetonitrile to afford cinnamic acids is reported. Only trans-β-arylacrylic acids were observed. A wide range of functionalized products can be effectively produced from various chalcones in good to excellent yields. © 2013 Sociedade Brasileira de Química.