Targeting glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy

Abstract

Carbohydrate-based dierapy, known as glycotherapeutics, is a new and emerging field diat promises to be the fixture hope for combating kinetoplastid infections more efficiently and effectively. Targeting novel glycoproteins/lipids, which are important disease determinants of kinetoplastid diseases, have helped in the development of this field. Better and refined understanding of all the available data would possibly help us in providing a future direction for rational drug design and better disease management. This review intends to focus on such lines, which will give us an insight into the future hope for development of novel therapeutic strategies through glycobiological platform for combating kinetoplastid infections. © 2008 Landes Bioscience and Springer Science+Business Media, LLC.