Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm

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Abstract

The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and an airblast to the throat as the unconditioned stimulus (US). Participants were extinguished 24 h after fear conditioning. Upon presentation of unsignaled USs after extinction, participants displayed significant fear reinstatement. In summary, these procedures produced robust fear-potentiated startle, significant CS+/CS-discrimination, within-session extinction, and significant reinstatement. This is the first demonstration of fear extinction and reinstatement in humans using startle measures. ©2006 by Cold Spring Harbor Laboratory Press.

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Norrholm, S. D., Jovanovic, T., Vervliet, B., Myers, K. M., Davis, M., Rothbaum, B. O., & Duncan, E. J. (2006). Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm. Learning and Memory, 13(6), 681–685. https://doi.org/10.1101/lm.393906

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