Neuroprotective effects of curcumin on sodium fluoride induced behavioural and enzymatic changes in brain and muscles of rat

Abstract

Aim: The study reports protective role of curcumin, a polyphenolic compound, against sodium fluoride (NaF) induced oxidative stress, altered cognitive, motor abilities and AChE, Na+-K+ATPase activities in rat. Methodology: Rats were divided into three groups. The first group received normal tap water that served as control. The second group was treated with sodium fluoride (20 mg kg-1 b. wt). The third group was treated with sodium fluoride (20 mg kg-1 b.wt.)+Curcumin (20 mg kg-1 b.wt.) through drinking water by gavagefor30days. Results: The body weight (-22.55%), somatic index (-15%,-26.72%), membrane bound enzymes Na+-K+ ATPase (-34.72%,-35.97%) and AChE activities (-44.70%,-38.83%) were significantly (p<0.05) decreased and oxidative stress marker lipid peroxidation level (67.96%,72.46%)was increased in sodium fluoride intoxicated group as compared to control group. The motor coordination (-43.18%,-39.90%), locomotor (-41.45%) and nociceptive pain (-14.78%,-15.98%) abilities were diminished in sodium fluoride treated group as compared to control group, whereas body weight, somatic index, membrane bound enzymes Na+-K+ ATPase, AChE activities, lipid peroxidation levels and motor coordination, locomotor and nociceptive pain abilities were significanly (p<0.05) reversed-in curcumi treated along witE sodium fluoride! group compared to NaF treated group. Interpretation: The results of the present study showed that curcumin ameliorated the oxidative stress, membrane bound enzyme activities in muscle and brain, as well as motor, pain and cognitive abilities of rat induced by NaF exposure.