Total synthesis and antimicrobial activity of (±)- laurelliptinhexadecan-1-one and (±)-laurelliptinoctadecan-1-one

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Abstract

The structures previously assigned to (+)-laurelliptinhexadecan-1-one (1a) and (+)-laurelliptinoctadecan-1-one (1b) from Cocculus orbiculatus (L.) DC. (Menispermaceae) have been confirmed by total synthesis of the racemic alkaloids. The key step of the synthesis involved formation of ring C of the aporphines by a radical-intiated cyclisation. Both (±)- laurelliptinhexadecan-1-one (1a) and (±)-laurelliptinoctadecan-1-one (1b) were inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028. © 2008 by the authors; licensee Molecular Diversity Preservation International.

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APA

Nimgirawath, S., Udomputtimekakul, P., Pongphuttichai, S., Wanbanjob, A., & Taechowisan, T. (2008). Total synthesis and antimicrobial activity of (±)- laurelliptinhexadecan-1-one and (±)-laurelliptinoctadecan-1-one. Molecules, 13(12), 2935–2947. https://doi.org/10.3390/molecules13122935

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