The serotonin (5-hydroxytryptamine, 5-HT) 2A receptor is most well known as the common target for classic psychedelic compounds. Interestingly, the 5-HT2A receptor is the most widely expressed mammalian serotonin receptor and is found in nearly every examined tissue type including neural, endocrine, endothelial, immune, and muscle, suggesting it could be a novel and pharmacological target for several types of disorders. Despite this, the bulk of research on the 5-HT2A receptor is focused on its role in the central nervous system (CNS). Recently, activation of 5-HT2A receptors has emerged as a new anti-inflammatory strategy. This review will describe recent findings regarding psychedelics as anti-inflammatory compounds, as well as parse out differences in functional selectivity and immune regulation that exist between a number of well-known hallucinogenic compounds.
CITATION STYLE
Flanagan, T. W., & Nichols, C. D. (2022). Psychedelics and Anti-inflammatory Activity in Animal Models. In Current Topics in Behavioral Neurosciences (Vol. 56, pp. 229–245). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/7854_2022_367
Mendeley helps you to discover research relevant for your work.