Synthesis and Analysis of Antimicrobial Properties of Isoxazoline

Abstract

I Abstract:-A simple procedure for the synthesis of isoxazole derivatives was developed. Cyclocondensation reaction of chalcones with hydroxylamine hydrochloride catalyzed by an acid produced isoxazoles. Chalcones were synthesized by the condensation product of acetophenone in combination with aromatic aldehydes in presence of strong base. The chalcone synthesized by base catalyzed condensation of 3-acetyl-6-methyl-2H-pyran-2,4-(3H) dione (DHA) with different aromatic aldehyde in good yields. These chalcones were used for synthesis of derivatives i.e. isoxazoline. The synthesized new compounds were characterized by spectral studies i.e. IR, 1 HNMR and mass spectral analysis and elemental analysis; before being were screened in vitro for their antimicrobial susceptibilities against different bacteria and fungi species. The derivatives were further used for the estimation of its biological properties. From the study it was found that the synthesized compounds are efficient for further research work.