DNA Methylation in Neurodegenerative Disorders

Abstract

Epigenetic mechanisms are essential in a host of biological processes and many different human diseases. Epigenetic modifications include DNA methylation, histone modification, non-coding RNA, and nucleosome positioning. In neuronal systems, extensive studies have revealed important regulatory roles of DNA methylation in brain function, from the embryonic stage through the process of aging. Here we review recent evidence that DNA methylation is involved in aging, learning and memory, and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and CGG repeat-induced neurodegenerative disorders. We also explore the dynamics of DNA methylation.