Epidermal Growth Factor Receptor in the Adult Brain

  • Estrada C
  • Villalobo A
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Abstract

The epidermal growth factor receptor (EGFR) plays a relevant role in brain development. Expression of EGFR and its ligands occurs in those regions in which neuronal and glial cells are generated, and EGFR activation is essential for the proliferation of multipotent neural precur- sors, as well as the survival, migration, and differentiation of the immature daughter cells. In the adult brain, EGFR is expressed in specific regions in physiological conditions. In the subven- tricular zone, where neurogenesis persists into adulthood, the EGFR contributes to the mainte- nance of the progenitor pool, and probably serves functions similar to those observed during development. Expression of both EGFR and its ligands is upregulated in different types of brain lesions where they may participate in brain self-repair by mechanisms that are not yet well understood. Finally, EGFR overexpression, as well as aberrant forms of the receptor, is present in a variety of cerebral tumors. Future research on cerebral EGFR function may lead to new therapeutic strategies in neurodegenerative or ischemic diseases and brain tumors.

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Estrada, C., & Villalobo, A. (2008). Epidermal Growth Factor Receptor in the Adult Brain. In The Cell Cycle in the Central Nervous System (pp. 265–277). Humana Press. https://doi.org/10.1007/978-1-59745-021-8_20

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