The discovery and development of induced pluripotent stem cells (iPSCs) opened a novel venue for disease modeling, drug discovery, and personalized medicine. Additionally, iPSCs have been utilized for a wide variety of research and clinical applications without immunological and ethical concerns that encounter embryonic stem cells. Adoptive T cell immunotherapy is a form of cellular immunotherapy that involves transfusion of functional T cells. However, this approach requires T cell expansion and the process causes T cell exhaustion. As a result, highly expanded T cells have not proven to be particularly effective for treatments. This exhaustion issue could be overcome due to rejuvenation of T cells by reprogramming to pluripotency and redifferentiation to T cells. This is a potential therapeutic strategy for combating various types of cancer.
CITATION STYLE
Nishimura, T., Murmann, Y., & Nakauchi, H. (2019). Human iPSC Generation from Antigen-Specific T Cells. In Methods in Molecular Biology (Vol. 2048, pp. 53–57). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9728-2_5
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