The effect of cobra venom factor (CVF) activation of the complement cascade on leukocyte circadian variation in the rat

Abstract

Administration of cobra venom factor (CVF) at different time periods over a 24-h-period produced a leukocytic response which varied according to the time of day the factor was given. The resulting leukocytic circadian rhythm was achieved by a marked variation and increase in the neutrophil population. © 1977 Birkhäuser Verlag.