Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-. N-acetylglucosamine (. O-GlcNAc) moieties. This sugar modification regulates fundamental cellular processes in response to diverse nutritional and hormonal cues. The enzymes O-GlcNAc transferase (OGT) and O-linked β-. N-acetylglucosaminase (. O-GlcNAcase) mediate the addition and removal of O-GlcNAc, respectively. Aberrant O-GlcNAcylation has been implicated in a plethora of human diseases, including diabetes, cancer, aging, cardiovascular disease, and neurodegenerative disease. Because metabolic dysregulation is a vital component of these diseases, unraveling the roles of O-GlcNAc in metabolism is of emerging importance. Here, we review the current understanding of the functions of O-GlcNAc in cell signaling and gene transcription involved in metabolism, and focus on its relevance to diabetes, cancer, circadian rhythm, and mitochondrial function. © 2013 Elsevier Ltd.
CITATION STYLE
Ruan, H. B., Singh, J. P., Li, M. D., Wu, J., & Yang, X. (2013, June). Cracking the O-GlcNAc code in metabolism. Trends in Endocrinology and Metabolism. https://doi.org/10.1016/j.tem.2013.02.002
Mendeley helps you to discover research relevant for your work.