Investigation of the functional retinal output using microelectrode arrays

Abstract

Microelectrode array (MEA) recordings of the ex vivo flat-mounted retina enable the functional analysis of the retinal output. The electrical activity of a large portion of retinal ganglion cells (RGCs) is recorded simultaneously in response to various light stimuli. Analysis of the recorded time series of action potentials reveals physiological parameters such as firing rate, time latency, receptive field size, axonal conduction velocity. These parameters change during retinal diseases.