3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 μm.
CITATION STYLE
Nguyen, G. V., Dang, H. T., Nguyen, L. D., Nguyen, H. V., Le, H. T., Nguyen, H. H. N., … Do, H. H. (2023). Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies. Mendeleev Communications, 33(4), 543–545. https://doi.org/10.1016/j.mencom.2023.06.033
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