Recent advances in microextraction techniques of antipsychotics in biological fluids prior to liquid chromatography analysis

25Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Antipsychotic drugs are a class of psychiatric medication worldwide used to treat psychotic symptoms principally in bipolar disorder, schizophrenia and other psycho-organic disorders. The traditional sample preparation techniques such as liquid-liquid extraction (LLE) or solid phase extraction (SPE), which were widely used, tend to have many drawbacks because they include complicated, time-consuming steps and they require large sample size as well large amounts of organic solvent. Therefore, due to the modern analytical requirements, such as miniaturization, automation and reduction of solvent volume and time, many microextraction procedures have been developed. In this review we aim to present an overview of those techniques which are used prior to liquid chromatography analyses both for forensic toxicology in different biological matrices as well as for therapeutic drug monitoring.

Cite

CITATION STYLE

APA

Manousi, N., Raber, G., & Papadoyannis, I. (2017, June 1). Recent advances in microextraction techniques of antipsychotics in biological fluids prior to liquid chromatography analysis. Separations. MDPI Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/separations4020018

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free