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Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk

Transcription (2011) 2(5) 207-210
DOI: 10.4161/trns.2.5.16813
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Abstract

The proto-oncogene MDM2 inhibits p53 and plays a key role in cell growth control and apoptosis. Identification of two antagonizing MDM2 polymorphisms, SNP285 and SNP309, affecting cancer risk through modulation of Sp1 transcription factor binding, shed new light on the biological activity and phylogeny of this gene. © 2011 Landes Bioscience.

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Knappskog, S., & Lønning, P. E. (2011). Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk. Transcription, 2(5), 207–210. https://doi.org/10.4161/trns.2.5.16813

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