X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation. © 2013 Nature America, Inc. All rights reserved.
CITATION STYLE
Vallot, C., Huret, C., Lesecque, Y., Resch, A., Oudrhiri, N., Bennaceur-Griscelli, A., … Rougeulle, C. (2013). XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells. Nature Genetics, 45(3), 239–241. https://doi.org/10.1038/ng.2530
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