Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease

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Abstract

Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to search for potential correlation between vitamin K status and pediatric IBD activity. Vitamin K status was assessed using protein induced by vitamin K absence-II (PIVKA-II; ELISA). Prevalence of vitamin K deficiency was 54.0% in CD and 43.7% in UC. Vitamin K deficiency was more common in patients with higher CD activity, in CD patients with higher mass Z-scores, and less common among children with CD treated with infliximab. Relation of vitamin K deficiency to pediatric IBD clinical course and treatment demand further research.

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Nowak, J. K., Grzybowska-Chlebowczyk, U., Landowski, P., Szaflarska-Poplawska, A., Klincewicz, B., Adamczak, D., … Walkowiak, J. (2014). Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease. Scientific Reports, 4. https://doi.org/10.1038/srep04768

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