Neuro-glio-vascular interaction in ischemic brains

8Citations
Citations of this article
24Readers
Mendeley users who have this article in their library.

Abstract

The brain contains glial cells (astrocytes, microglia, and oligodendrocytes) and endothelial cells in addition to neurons. Under various pathologic conditions, the invasion of leukocytes such as neutrophils, monocytes/macrophages, and lymphocytes is observed. Interactions among these cell types play crucial roles both in brain function and dysfunction. However, the molecular basis of such interactions remains unclear. Cytokines and chemokines were originally identified as essential mediators of in‰ammatory and immune responses. Enhanced production and release of cytokines/ chemokines are observed also in the central nervous system under various pathologic conditions. There is growing evidence showing that brain cytokines/chemokines play crucial roles in the neuro-glio-vascular interaction underlying the pathology of various brain disorders and therefore are potential targets for the development of novel and effective therapeutics for central nervous system diseases. This article REs the evidence for the involvement of cytokines/ chemokines in ischemic brain injury and presents our data on introducing organotypic brain slice cultures and in vitro blood brain barrier models as useful tools to investigate neuro-glio-vascular interaction. © 2011 The Pharmaceutical Society of Japan.

Cite

CITATION STYLE

APA

Minami, M. (2011). Neuro-glio-vascular interaction in ischemic brains. Yakugaku Zasshi. https://doi.org/10.1248/yakushi.131.539

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free