Formation of host-guest complex of cucurbit[7]uril with cytosine

Abstract

Interaction between cucurbit[7]uril (Q[7]) and cytosine in aqueous solution was investigated by 1H NMR spectroscopy, UV absorption spectroscopy and HPLC analysis. The 1H NMR analysis indicated that Q[7] selectively interacted with the cytosine moiety of the guest. UV absorption spectroscopy proved the formation of 1:1 inclusion complexes of Q[7]@guest. HPLC method was also introduced to explore the interaction between Q[7] and the cytosine.