Cell mediated cytotoxicity against murine cells infected with 6/94 virus, a parainfluenza type 1 isolate from multiple sclerosis brain tissue

Abstract

Maximum cytotoxicity to parainfluenza type 1 viral determinants occurs on day 5 post immunization in mice with and without preexisting anti 6/94 virus antibody. Animals with preexisting anti 6/94 serum antibody, however, exhibited a markedly higher cytotoxic response. Syngeneic, allogeneic, and xenogeneic virus infected cells induce virus specific cytotoxicity, but only infected cells histocompatible with the effector cells can serve as susceptible target cells. The effector cell is a T cell, and hence cytotoxicity is thymus dependent. Coincident with the maximum cytotoxic activity on day 5 is the occurrence of pathologic lesions, the sites of which are dependent on the route of inoculation.