Interaction of Nuclei and Globulin from Lupus Erythematosis Serum Demonstrated with Fluorescent Antibody

Abstract

Using the fluorescent antibody technique a globulin component with a marked affinity for nuclei has been demonstrated in serum of patients with disseminated lupus erythematosis. It has been shown that the factor reacts with nuclei of most tissues of a wide range of vertebrate species. Information on the occurrence of the factor in 100 human sera is reported.