Cytotoxic evaluation of natural and synthetic callipeltins: A revision of cytotoxicity of callipeltin B

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Abstract

The cytotoxic evaluation of natural and synthetic callipeltins is described. Cyclic depsipeptide callipeltin B and linear peptides callipeltins E and M synthesized by us showed no cytotoxic activity. In contrast, natural callipeltin B purified from Callipelta sp. showed CC50 = 130 μM against Hela cells. We found that purified callipeltin B included the contamination of callipeltins C and H at a ratio of approximately 15%. These results suggested that the cytotoxicity of natural callipeltin B was derived from callipeltins C and H.

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Kikuchi, M., & Konno, H. (2016). Cytotoxic evaluation of natural and synthetic callipeltins: A revision of cytotoxicity of callipeltin B. Bioscience, Biotechnology and Biochemistry, 80(6), 1066–1069. https://doi.org/10.1080/09168451.2016.1148581

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