Cutting Edge: Primary and Secondary Effects of CD19 Deficiency on Cells of the Marginal Zone

  • You Y
  • Zhao H
  • Wang Y
  • et al.
37Citations
Citations of this article
44Readers
Mendeley users who have this article in their library.

Abstract

Marginal zone (MZ) B cells are absent in CD19−/− mice. Possible causes include an intrinsic defect in B cells and/or a secondary defect in the extrinsic MZ microenvironment as a result of changes in B cell differentiation in mice lacking CD19. Cells in the MZ also include MZ macrophages (MZM) and MZ dendritic cells (DC). Although CD19 is only expressed on B cells, SIGN-R1+ MZM are absent and CD11c+ MZ DC distribution is abnormal in CD19−/− mice. Adoptively transferred B cells from normal mice are able to reconstitute MZ B cells in CD19−/− mice. In contrast, CD19−/− B cells could not enter the MZ of the normal mice. Furthermore, MZM distribution and MZ DC distribution are restored following MZ B cell reconstitution in CD19−/− mice. Thus, MZ B cells are required for MZM differentiation and MZ DC localization, but the deficiency of MZ B cells in CD19−/− mice is caused by a defect of intrinsic B cell signaling.

Cite

CITATION STYLE

APA

You, Y., Zhao, H., Wang, Y., & Carter, R. H. (2009). Cutting Edge: Primary and Secondary Effects of CD19 Deficiency on Cells of the Marginal Zone. The Journal of Immunology, 182(12), 7343–7347. https://doi.org/10.4049/jimmunol.0804295

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free