Pancreatic ductal adenocarcinoma remains an unyielding adversary, with a 5-year survival of 5%, a figure unchanged in 50 years. Characterised by marked genetic heterogeneity, recent genomic sequencing efforts demonstrate that with the exclusion of a few known mutations, most mutations occur at a prevalence of <5%. Current systemic chemotherapeutics, when used in an all-comer approach, are at best modestly effective, yet are associated with responses in small groups of undefined patients. Defining these subgroups and targeting them with the appropriate therapy in a personalized or stratified approach holds the promise of improved outcomes for this disease. © Informa UK, Ltd.
CITATION STYLE
Jamieson, N. B., Chang, D. K., Grimmond, S. M., & Biankin, A. V. (2014). Can we move towards personalised pancreatic cancer therapy? Expert Review of Gastroenterology and Hepatology. Expert Reviews Ltd. https://doi.org/10.1586/17474124.2014.893820
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