Actin stress fibers

583Citations
Citations of this article
880Readers
Mendeley users who have this article in their library.

Abstract

Animal cell movement is effected through a combination of protrusive and contractile events. Non-muscle cells contain stress fibres - bundles of actomyosin that are the major mediators of cell contraction and that can be compared to the highly organised actomyosin arrays of muscle cells. Recent studies have defined regulatory mechanisms that control stress fibre formation, placing the ROCK protein kinase at the centre of a complex signalling network controlling actomyosin contractility and stress fibre assembly. As we uncover the details of stress fibre construction, it is becoming clear that different categories of stress fibres exist. Some of these structures are less suited for cell motility and more suited to static contraction. In keeping with this, many specialised contractile cell types use stress fibres to remodel tissues and extracellular matrix.

References Powered by Scopus

Cell Migration: Integrating Signals from Front to Back

4076Citations
N/AReaders
Get full text

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho- kinase)

2524Citations
N/AReaders
Get full text

The myofibroblast: One function, multiple origins

1779Citations
N/AReaders
Get full text

Cited by Powered by Scopus

TGF-Β-induced epithelial to mesenchymal transition

2294Citations
N/AReaders
Get full text

Environmental sensing through focal adhesions

2048Citations
N/AReaders
Get full text

Filopodia: Molecular architecture and cellular functions

1349Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Pellegrin, S., & Mellor, H. (2007). Actin stress fibers. Journal of Cell Science, 120(20), 3491–3499. https://doi.org/10.1242/jcs.018473

Readers over time

‘08‘09‘10‘11‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘24‘250255075100

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 435

70%

Researcher 124

20%

Professor / Associate Prof. 54

9%

Lecturer / Post doc 7

1%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 298

49%

Biochemistry, Genetics and Molecular Bi... 172

28%

Physics and Astronomy 68

11%

Engineering 66

11%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1
References: 1

Save time finding and organizing research with Mendeley

Sign up for free
0