Inhibition effect of a custom peptide on lung tumors

7Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a could significantly inhibit the growth of tumors in this in vivo model. Docetaxel is a drug in present clinical use against lung cancers; it can have serious side effects because its toxicity is not sufficiently limited to cancer cells. In our studies in mice: CB1a is more toxic to cancer cells than docetaxel, but dramatically less toxic to healthy cells.

Cite

CITATION STYLE

APA

Huang, C. Y., Huang, H. Y., Forrest, M. D., Pan, Y. R., Wu, W. J., & Chen, H. M. (2014). Inhibition effect of a custom peptide on lung tumors. PLoS ONE, 9(10). https://doi.org/10.1371/journal.pone.0109174

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free