Clinical outcomes in neonates following maternal magnesium sulfate therapy in preeclampsia/eclampsia

Abstract

Magnesium sulfate therapy (MST) is the method of choice in prophylaxis and treatment of eclamptic seizures in many countries. A lot of high-quality clinical trials and meta-analyses proved its efficacy and safety for mothers. But the effect of maternal MST on the fetus and neonate is still controversial. The goal of the study was to analyze available trials concerning this problem in order to prove statistically that maternal MST given as prophylaxis or treatment of eclamptic seizures has no adverse effects on the mature fetus and term neonate.