The amphiphilic triblock copolymer of poly(σ -caprolactone)-b- poly(ethylene glycol)-bpoly( σ -caprolactone) (PCL-PEG-PCL) was prepared by ring opening polymerization of PEG and σ -caprolactone in the presence of stannous 2-ethyl hexanoate (Sn(Oct)2) as catalyst. The structure of triblock copolymer was characterized by proton nuclear magnetic resonance (1HNMR), Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The polymeric nanoparticles were prepared in aqueous solution by a co-solvent precipitation technique at room temperature. Nanoparticles were formed from the amphiphilic triblock copolymer, and the effect of organic solvent water-miscibility on the size of nanoparticles was also investigated. Polymeric nanoparticles were measured by dynamic light scattering (DLS), with sizes in the range of 70-90 nm and narrow polydispersity. Additionally, the toxicities of polymeric micelles were evaluated by MTT assay. These results confirmed low toxic polymeric micelles and suggest that the polymeric micelles hold a potential for anticancer drug delivery. © 2010 Vietnam Academy of Science & Technology.
CITATION STYLE
Nguyen, T. H. A., & Nguyen, V. C. (2010). Formation of nanoparticles in aqueous solution from poly(σ- caprolactone)- poly(ethylene glycol)-poly(σ-caprolactone). Advances in Natural Sciences: Nanoscience and Nanotechnology, 1(2). https://doi.org/10.1088/2043-6254/1/2/025012
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