Formation of nanoparticles in aqueous solution from poly(σ- caprolactone)- poly(ethylene glycol)-poly(σ-caprolactone)

18Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The amphiphilic triblock copolymer of poly(σ -caprolactone)-b- poly(ethylene glycol)-bpoly( σ -caprolactone) (PCL-PEG-PCL) was prepared by ring opening polymerization of PEG and σ -caprolactone in the presence of stannous 2-ethyl hexanoate (Sn(Oct)2) as catalyst. The structure of triblock copolymer was characterized by proton nuclear magnetic resonance (1HNMR), Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The polymeric nanoparticles were prepared in aqueous solution by a co-solvent precipitation technique at room temperature. Nanoparticles were formed from the amphiphilic triblock copolymer, and the effect of organic solvent water-miscibility on the size of nanoparticles was also investigated. Polymeric nanoparticles were measured by dynamic light scattering (DLS), with sizes in the range of 70-90 nm and narrow polydispersity. Additionally, the toxicities of polymeric micelles were evaluated by MTT assay. These results confirmed low toxic polymeric micelles and suggest that the polymeric micelles hold a potential for anticancer drug delivery. © 2010 Vietnam Academy of Science & Technology.

Cite

CITATION STYLE

APA

Nguyen, T. H. A., & Nguyen, V. C. (2010). Formation of nanoparticles in aqueous solution from poly(σ- caprolactone)- poly(ethylene glycol)-poly(σ-caprolactone). Advances in Natural Sciences: Nanoscience and Nanotechnology, 1(2). https://doi.org/10.1088/2043-6254/1/2/025012

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free