Uterine synechia: A preliminary communication on an attempted treatment of the condition with intrauterine instillation of autologous bone marrow mononuclear cells

Abstract

The uterine cavity is lined by the endometrium. This lining is composed of two layers, the functional layer (adjacent to the uterine cavity) which is shed during menstruation and an underlying basal layer (adjacent to the myometrium) which is necessary for regenerating the functional layer. Thorough curettage and removal/partial removal of the basal layer often leads to a condition known as synechia, or Asherman’s syndrome (AS) or Fritsch syndrome, where there is intrauterine adhesion of the walls of the uterus, as a result of which the estrogen-sensitive areas are lost leading to a condition where patients experience secondary menstrual irregularities characterized by a decrease in flow and duration of bleeding (amenorrhea, hypomenorrhea, or oligomenorrhea).