Vitamin D receptor fokI, BsmI, ApaI, and TaqI polymorphisms and the susceptibility to breast cancer: A meta-analysis

Abstract

The goal of this study is to examine whether vitamin D receptor (VDR) polymorphisms are associated with the susceptibility to breast cancer. Meta-analysis was employed to investigate the association between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and the incidence of breast cancer. A total of 32 comparative studies were evaluated in this meta-analysis, which included 17,067 patients and 20,843 controls. Meta-analysis of the VDR FokI polymorphism indicated an association between the incidence of breast cancer and the ff genotype in Europeans (OR = 1.126, 95% CI = 1.026–1.243, p = 0.019) Furthermore, an association between the incidence of breast cancer and the VDR FokI polymorphism was found in the Europeans using the allele contrast, as well as the homozygote contrast. However, the meta-analysis indicated no association between breast cancer and the BsmI polymorphism in all study subjects, including the Europeans (OR for the B allele = 0.996, 95% CI = 0.964–1.097, p = 0.930, 1.026, 95% CI = 0.929–1.134, p = 0.610). Moreover, breast cancer incidence was not associated with the ApaI and Taq polymorphisms (OR for the A allele = 0.908, 95% CI = 0.763–1.041, p = 0.167, OR for the T allele = 0.972, 95% CI = 0.929–1.017, p = 0.221). This meta-analysis suggests that the VDR FokI polymorphism is associated with susceptibility to breast cancer in the European population.