Genetic Aspects of Male Infertility

Abstract

The genes and genomic regulation involved in male genital tract development, gonadal development, and function including those related to spermatogenesis have been implicated as causal factors in male infertility. It has been estimated that genetic abnormalities may account for 15-30% of male factor infertility. As many of the genetic factors are elucidated, more and more information will become relevant to daily clinical applications. Thus, it is essential to appraise the current genetic basis of male reproductive system disorders to help guide the future use of genetic treatments for male infertility.