Motor Impairments Related to Brain Injury Timing in Early Hemiparesis. Part II

  • Sukal-Moulton T
  • Krosschell K
  • Gaebler-Spira D
  • et al.
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Abstract

Background. Extensive neuromotor development occurs early in human life, and the timing of brain injury may affect the resulting motor impairment. In Part I of this series, it was demonstrated that the distribution of weakness in the upper extremity depended on the timing of brain injury in individuals with childhood-onset hemiparesis. Objective. The goal of this study was to characterize how timing of brain injury affects joint torque synergies, or losses of independent joint control. Method. Twenty-four individuals with hemiparesis were divided into 3 groups based on the timing of their injury: before birth (PRE-natal, n = 8), around the time of birth (PERI-natal, n = 8), and after 6 months of age (POST-natal, n = 8). Individuals with hemiparesis and 8 typically developing peers participated in maximal isometric shoulder, elbow, wrist, and finger torque generation tasks while their efforts were recorded by a multiple degree-of-freedom load cell. Motor output in 4 joints of the upper extremity was concurrently measured during 8 primary torque generation tasks to quantify joint torque synergies. Results. There were a number of significant coupling patterns identified in individuals with hemiparesis that differed from the typically developing group. POST-natal differences were most noted in the coupling of shoulder abductors with elbow, wrist, and finger flexors, while the PRE-natal group demonstrated significant distal joint coupling with elbow flexion. Conclusion. The torque synergies measured provide indirect evidence for the use of bulbospinal pathways in the POST-natal group, while those with earlier injury may use relatively preserved ipsilateral corticospinal motor pathways.

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Sukal-Moulton, T., Krosschell, K. J., Gaebler-Spira, D. J., & Dewald, J. P. A. (2014). Motor Impairments Related to Brain Injury Timing in Early Hemiparesis. Part II. Neurorehabilitation and Neural Repair, 28(1), 24–35. https://doi.org/10.1177/1545968313497829

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