The Recognition of Hypothalamo-Neurohypophysial Functions By Developing T Cells

32Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

Neuropeptide signals and specific neuropeptide receptors have been described in the thymus supporting the concept of a close dialogue between the neuroendocrine and the immune systems at the level of early T-cell differentiation. In this paper, we review recent data about neurohypophysial (NHP)-related peptides detected in the thymus from different species. We suggest that we are dealing in fact with other member(s) of the NHP hormone family, which seems to exert its activity locally through a novel model of cell-to-cell signaling, that of cryptocrine communication. This model involves exchange of signals between thymic epithelial cells and developing thymocytes. The NHP-related peptides have been shown to trigger thymocyte proliferation and could induce immune tolerance of this highly conserved neuroendocrine family. © 1992, Harwood Academic Publishers GmbH.

Cite

CITATION STYLE

APA

Robert, F. R., Martens, H., Cormann, N., Benhida, A., Schoenen, J., & Geenen, V. (1992). The Recognition of Hypothalamo-Neurohypophysial Functions By Developing T Cells. Developmental Immunology, 2(2), 131–140. https://doi.org/10.1155/1992/98671

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free