The combination of smart polymers with molecular imprinting offers a powerful tool to design more effective sensors and medical devices. In this study, a temperature sensitive amine-terminated poly(N-isopropylacrylamide) block with (N,N'-methylenebisacrylamide) cross-linker along with o-phenylenediamine was electropolymerised on a gold electrode in the presence of folic acid (FA) as template to produce an on/off-switchable molecularly imprinted polymer (MIP) affinity sensor for folic acid. Differential pulse voltammetry and cyclic voltammetry were used to characterise the FA-imprinted layer. Incubation of the MIP-modified electrode with FA resulted in a suppression of the ferro/ferricyanide redox process. The highest sensitivity of this temperature gated on/off-switchable folic acid sensor was achieved at 22 C. Such switchable affinity materials offer considerable potential for the design of highly selective and controllable biosensors and immunoassays. © 2013 Elsevier B.V.
CITATION STYLE
Karimian, N., Zavar, M. H. A., Chamsaz, M., Turner, A. P. F., & Tiwari, A. (2013). On/off-switchable electrochemical folic acid sensor based on molecularly imprinted polymer electrode. Electrochemistry Communications, 36, 92–95. https://doi.org/10.1016/j.elecom.2013.09.014
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