Blockade of the immunological checkpoint programmed death 1 (PD-1) using monoclonal antibodies has shown robust anti-tumor activity across a broad range of solid and hematological malignancies including melanoma and renal cell carcinoma (RCC). Characteristic markers such as the presence of tumor infiltrating lymphocytes, PD-L1 status, and mutational load may be equally or even more important in predicting clinical benefit from PD-1 pathway blockade than tumor histology. This case of a patient with concurrent metastatic melanoma and metastatic RCC, both of which were controlled for more than a year after a single dose of the anti-PD-1 antibody pembrolizumab, illustrates the potential to simultaneously treat distinct immunogenic tumors with anti-PD-1 agents.
CITATION STYLE
Marmarelis, M. E., Davis, M. R., Sethi, N. S., Krajewksi, K. M., McKay, R. R., Choueiri, T. K., & Ott, P. A. (2016). Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma. Journal for ImmunoTherapy of Cancer, 4(1). https://doi.org/10.1186/s40425-016-0129-x
Mendeley helps you to discover research relevant for your work.