Multiple, complementary techniques for tumor detection, including magnetic resonance, nuclear and optical imaging, are under active development; each approach has particular strengths and advantages. Efforts are also currently underway to develop bifunctional agents, so that a single molecule can be used for imaging, therapy, and monitoring the long-term tumor response. This chapter is mainly focused on illustrating the utility of certain tumor-avid photosensitizers in developing agents for tumor imaging [fluorescence, magnetic resonance imaging (MRI), positron emission tomography (PET)] and photodynamic therapy. Recent approaches for developing target-specific agents for photodynamic therapy (PDT) and in vivo tumor imaging are also briefly discussed. © 2010 Springer Science+Business Media, LLC.
CITATION STYLE
Pandey, R. K., James, N. S., Chen, Y., Missert, J., & Sajjad, M. (2010). Bifunctional agents for imaging and therapy. Methods in Molecular Biology, 635, 223–259. https://doi.org/10.1007/978-1-60761-697-9_16
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