In vitro antioxidant activity and scavenging effects of some synthesized 4-Aminochalcones

Abstract

A new series of substituted 4'-aminochalcones were synthesized by Claisen-Schmidt condensation of 4-aminoacetophenone with various substituted aromatic/heteroaromatic aldehydes. The antioxidant activity for all these compounds were studied on various reactive oxygen species assays containing superoxide anion, hydroxyl radical, ABTS cation radical scavenging and inhibition of lipid peroxidation assays. Chalcones 9 and 10 made up of 3,4,5-trimethoxyphenyl and 4-dimethylaminophenyl moieties as ring-B of chalcones respectively exhibited maximum activity in various antioxidant assays, which may be due to the free radical scavenging activity. The present study revealed that an electron releasing group at position 4 of the ring B of chalcone is essential for exhibiting significant antioxidant activity.