Effect of transforaminal epidural polydeoxyribonucleotide injections on lumbosacral radiculopathy: A case report

Abstract

Rationale:Transforaminal epidural glucocorticoids administration is widely performed for the management of lumbosacral radiculopathy. However, it may worsen the condition of patients with type 2 diabetes mellitus (DM). Polydeoxyribonucleotide (PDRN) was recently noted as a substitute for glucocorticoids.Patient concerns:A 44-year-old male patient was admitted to our pain clinic with symptoms of low back pain with severe pain and tingling sensation of left posterolateral leg. He had type 2 DM medicated with Glimepiride and Metformin. Blood glucose level was 367mg/dL. He declined to use glucocorticoid.Diagnoses:He was diagnosed as left foraminal disc protrusion at L4-5, left subarticular disc protrusion at L5-S1.Interventions:Fluoroscopically guided transforaminal epidural PDRN injections were carried out.Outcomes:The patient was followed up for more than 6 months and demonstrated good improvement in lumbosacral radiculopathy without any complications.Lessons:This is the first successful report on epidural injection of PDRN.