KOKRISTALISASI ASPIRIN DAN ASAM TARTRAT DENGAN METODE PENGUAPAN PELARUT

Abstract

Co-crystallization of aspirin and tartic acid as a coformer has been attempted. The purpose of this study was to improve the dissolution of aspirin (ASP), which is classified as a BCS class II compound with a high permeability but a low solubility. The cocrystal formation of ASP and tartaric acid was made in a molar ratio of 1:1, 1:2, and 2:1 using the solvent evaporation method. The obtained crystals were then characterized using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and fourier transform infra-red (FTIR) spectrophotometry. In accordance with the FTIR data, there was no spectrum shifting between conventional ASP functional groups and crystalline solids. When comparing cocrystal solids to conventional ASP, the DSC thermogram revealed no differences in thermal behavior. There were no new peaks or unusual diffractogram patterns from the standard ASP as shown by the PXRD diffractogram analysis, hence it could be inferred that no cocrystal phase was formed. The dissolution rate of 1:1 molar ratio was increased by 78.56 % after 30 minutes as compared to conventional ASP, according to the findings of a dissolution test. The increase in the dissolution rate at the molar ratio of 1:1 is due to the formation of a eutectic mixture between ASP and tartaric acid