Electrochemical study of indapamide and its complexation with β-cyclodextrin

Abstract

Electrochemical oxidation of indapamide has been investigated at glassy carbon electrode using cyclic and differential pulse voltammetry (DPV). Indapamide exhibited two well resolved signals which attributed to the oxidation of indoline ring and benzamide moiety in phosphate buffers in the pH range of 2.7-10.1. The oxidation processes have been shown to be irreversible and diffusion controlled. The formation of an inclusion complex of indapamide with β-cyclodextrin (β-CD) has been investigated by cyclic, differential pulse voltammetry as well as UV-Vis spectrophotometry. The stability constant of the complex was determined to be 6199 and 2717 M-1 using differential pulse voltammetry and UV-Vis spectrophotometry, respectively. © 2010 Springer Science+Business Media B.V.