Toxic epidermal necrolysis is a condition with massive keratinocyte apoptosis, and it is associated with high mortality rates. Fulvestrant, an estrogen receptor antagonist, is indicated in the treatment of estrogen receptor-positive metastatic breast cancer in postmenopausal women. To our knowledge, this is the first described case of toxic epidermal necrolysis due to fulvestrant. A 56-year-old woman received 500 mg of intramuscular fulvestrant monthly for metastatic ductal carcinoma of the breast. Five days after the first dose, the patient presented with a maculopapular rash that evolved to blisters, and a detachment of the epidermis in over 30% of the total body surface area. Histological analysis was compatible with toxic epidermal necrolysis. Fulvestrant was discontinued, topical management and supportive care were initiated.
CITATION STYLE
Morales-Conde, M., López-Ibáñez, N., Calvete-Candenas, J., & Mendonça, F. M. I. (2019). Fulvestrant-induced toxic epidermal necrolysis. Anais Brasileiros de Dermatologia, 94(2), 218–220. https://doi.org/10.1590/abd1806-4841.20197964
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